Unveiling a rare haemorrhagic malignant pleural effusion: The role of medical thoracoscopy in diagnosing primary pleural angiosarcoma

Autor: Ad Rian Chong, Khai Lip Ng, Nai‐Chien Huan, Nur Husna Mohd Aminudin, Maryam Ahmad Sharifuddin, Raja Nor Adilla Raja Rahaizat, Kasuma Mohamed Nordin
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Respirology Case Reports, Vol 12, Iss 11, Pp n/a-n/a (2024)
Druh dokumentu: article
ISSN: 2051-3380
DOI: 10.1002/rcr2.70068
Popis: Abstract Primary pleural angiosarcoma (PPA) is a rare and challenging tumour to diagnose, often mistaken for other malignancies such as mesothelioma and lung cancer due to overlapping clinical and imaging features. We report a 52‐year‐old woman who presented with progressive shortness of breath and pleuritic chest pain. Imaging studies and thoracentesis revealed a large haemorrhagic left pleural effusion. Medical thoracoscopy (MT) showed a thickened and lobulated parietal pleura with multiple nodular lesions. Histopathological examination confirmed a diagnosis of angiosarcoma, characterized by pleomorphic tumour cells, a high Ki67 proliferation index and positive immunohistochemical markers, including CD31, D2‐40, Vimentin, and Factor VIII. Tragically, the patient developed a hospital‐acquired infection and passed away before any definitive treatment for the angiosarcoma could be initiated. This case underscores the diagnostic complexities of PPA and highlights the utility of MT in identifying this rare malignancy.
Databáze: Directory of Open Access Journals
Nepřihlášeným uživatelům se plný text nezobrazuje