Visual spatial learning outcomes for clinical trials in neurofibromatosis type 1

Autor:	Nicole J. Ullrich, Jonathan M. Payne, Karin S. Walsh, Gary Cutter, Roger Packer, Kathryn North, Celiane Rey‐Casserly, the NF Clinical Trials Consortium
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Zdroj:	Annals of Clinical and Translational Neurology, Vol 7, Iss 2, Pp 245-249 (2020)
Druh dokumentu:	article
ISSN:	2328-9503
DOI:	10.1002/acn3.50976
Popis:	Abstract Cognitive problems are common in children with neurofibromatosis type 1, representing a significant source of lifelong morbidity. Assessment of cognitive function has been challenging in the setting of clinical trials. Spatial learning deficits may be an important target for cognitive interventions. We leveraged a large, international cognitive study in affected children with NF1 treated with lovastatin to assess spatial learning using the “Arena Maze”, a portable, computerized task that allows for retesting in the same environment. As with the parent study, spatial learning assessed with this task did not improve with lovastatin treatment.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/5b56a8ae38094423909c1dd7cfb8ee7e Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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