Impact of Mitral Regurgitation Severity and Cause on Effort Tolerance–Integrated Stress Myocardial Perfusion Imaging and Echocardiographic Assessment of Patients With Known or Suspected Coronary Artery Disease Undergoing Exercise Treadmill Testing

Autor: Polydoros N. Kampaktsis, Benjamin J. Albert, Jiwon Kim, Lola X. Xie, Lillian R. Brouwer, Nathan H. Tehrani, Michael Villanueva, Daniel Y. Choi, Massimiliano Szulc, Mark B. Ratcliffe, Robert A. Levine, Richard B. Devereux, Jonathan W. Weinsaft
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 8, Iss 5 (2019)
Druh dokumentu: article
ISSN: 2047-9980
DOI: 10.1161/JAHA.118.010974
Popis: Background Mitral regurgitation (MR) has the potential to impede exercise capacity; it is uncertain whether this is because of regurgitation itself or the underlying cause of valvular insufficiency. Methods and Results The population comprised 3267 patients who underwent exercise treadmill myocardial perfusion imaging and transthoracic echocardiography within 6±8 days. MR was present in 28%, including 176 patients (5%) with moderate or greater MR. Left ventricular systolic function significantly decreased and chamber size increased in relation to MR, paralleling increments in stress and rest myocardial perfusion deficits (all P
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