Gastric immune homeostasis imbalance: An important factor in the development of gastric mucosal diseases

Autor: Shuhui Liu, Zilin Deng, Jiaxing Zhu, Zhiyuan Ma, Biguang Tuo, Taolang Li, Xuemei Liu
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Biomedicine & Pharmacotherapy, Vol 161, Iss , Pp 114338- (2023)
Druh dokumentu: article
ISSN: 0753-3322
DOI: 10.1016/j.biopha.2023.114338
Popis: The gastric mucosal immune system is a unique immune organ independent of systemic immunity that not only maintains nutrient absorption but also plays a role in resisting the external environment. Gastric mucosal immune disorder leads to a series of gastric mucosal diseases, including autoimmune gastritis (AIG)-related diseases, Helicobacter pylori (H. pylori)-induced diseases, and various types of gastric cancer (GC). Therefore, understanding the role of gastric mucosal immune homeostasis in gastric mucosal protection and the relationship between mucosal immunity and gastric mucosal diseases is very important. This review focuses on the protective effect of gastric mucosal immune homeostasis on the gastric mucosa, as well as multiple gastric mucosal diseases caused by gastric immune disorders. We hope to offer new prospects for the prevention and treatment of gastric mucosal diseases.
Databáze: Directory of Open Access Journals