Moutan cortex radicis extract alleviates lipid accumulation by modulating endoplasmic reticulum stress in high-fat diet-fed mice

Autor: Miaomiao Bai, Hongnan Liu, Changfeng Peng, Yirui Shao, jinjie Hu, Yueyao Xing, Junhong Liu, Kang Xu, Xia Xiong, Xiangfeng Kong
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Journal of Functional Foods, Vol 119, Iss , Pp 106346- (2024)
Druh dokumentu: article
ISSN: 1756-4646
DOI: 10.1016/j.jff.2024.106346
Popis: To analyse the effects of Moutan cortex radicis extract (ME) on lipid metabolism disorder via regulation of lipid accumulation and endoplasmic reticulum stress (ERS). C57BL/6 mice were fed an HFD for 11 weeks and then an HFD plus 200 mg/kg ME for 2 weeks. We found that ME reduced hepatic CHOL levels and lipid droplet deposition, and down-regulated PPARγ, SCD1, GRP78 and C/EBP compared to the HFD group (P
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