| Autor: |
Jinbo Li, Akram Ayoub, Yan Xiu, Xiaoxiang Yin, James O. Sanders, Addisu Mesfin, Lianping Xing, Zhenqiang Yao, Brendan F. Boyce |
| Jazyk: |
angličtina |
| Rok vydání: |
2019 |
| Předmět: |
|
| Zdroj: |
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019) |
| Druh dokumentu: |
article |
| ISSN: |
2041-1723 |
| DOI: |
10.1038/s41467-019-10677-0 |
| Popis: |
Increased inflammation during ageing promotes osteoporosis by activating osteoclast function and inhibiting osteoblasts. Here, the authors show that TGFβ1 release from bone matrix during ageing induces degradation of TRAF3 in mesenchymal progenitor cells, leading to reduced osteoblast differentiation and increased osteoclast formation, and suggesting that pharmacological stabilization of TRAF3 could ameliorate age-related osteoporosis. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
