| Autor: |
Wen Jun Jerome Bin, Aloysius Chow, Helen Elizabeth Smith, Eng Sing Lee |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
Annals, Academy of Medicine, Singapore, Vol 53, Iss 7, Pp 446-453 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2972-4066 |
| DOI: |
10.47102/annals-acadmedsg.2023252 |
| Popis: |
Introduction: The under-representativeness of participants in clinical trials limits the generalisability of results. This review evaluates the representativeness within pharmaceutical randomised controlled trials (RCTs) in Singapore. Method: Four bibliographic databases were searched for papers on pharmaceutical RCTs which included Singapore adults (≥18 years old), published between 2017 and 2022. The demographic characteristics of study participants were compared against the population in the 2020 Singapore census. Recruitment strategies and authors’ comments on the generalisability of their findings were reviewed. Results: Thirty-three publications were included (19 Singapore-only studies and 14 multiregional trials which included Singapore). Where data were available, we found that females and Indians were under-represented compared to the census (41.3% versus [vs] 51.1%, P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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