CD28 engagement inhibits CD73-mediated regulatory activity of CD8+ T cells

Autor: Yo-Ping Lai, Lu-Cheng Kuo, Been-Ren Lin, Hung-Ju Lin, Chih-Yu Lin, Yi-Ting Chen, Pei-Wen Hsiao, Huan-Tsung Chang, Patrick Chow-In Ko, Hsiao-Chin Chen, Hsiang-Yu Chang, Jean Lu, Hong-Nerng Ho, Betty A. Wu-Hsieh, John T. Kung, Shu-Ching Chen
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Druh dokumentu: article
ISSN: 2399-3642
DOI: 10.1038/s42003-021-02119-9
Popis: Lai et al. report that the immunosuppressive molecule CD73 is negatively regulated by CD28 costimulation during CD8+ T cell activation. Their study implicates a lack of CD28 costimulation renders CD8+ T cells immunosuppressive and less able to eliminate solid tumors.
Databáze: Directory of Open Access Journals
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