Regioselective Mercury(I)/Palladium(II)-Catalyzed Single-Step Approach for the Synthesis of Imines and 2-Substituted Indoles

Autor:	Rsuini U. Gutiérrez, Mayra Hernández-Montes, Aarón Mendieta-Moctezuma, Francisco Delgado, Joaquín Tamariz
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	mercury(I)-catalyzed alkyne hydroamination imines Pd-catalyzed oxidative cyclization one-pot indole synthesis Organic chemistry QD241-441
Zdroj:	Molecules, Vol 26, Iss 13, p 4092 (2021)
Druh dokumentu:	article
ISSN:	1420-3049
DOI:	10.3390/molecules26134092
Popis:	An efficient synthesis of ketimines was achieved through a regioselective Hg(I)-catalyzed hydroamination of terminal acetylenes in the presence of anilines. The Pd(II)-catalyzed cyclization of these imines into the 2-substituted indoles was satisfactorily carried out by a C-H activation. In a single-step approach, a variety of 2-substituted indoles were also generated via a Hg(I)/Pd(II)-catalyzed, one-pot, two-step process, starting from anilines and terminal acetylenes. The arylacetylenes proved to be more effective than the alkyl derivatives.
Databáze:	Directory of Open Access Journals
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