Immunogenicity of mRNA-1273 and BNT162b2 in Immunocompromised Patients: Systematic Review and Meta-analysis Using GRADE

Autor:	Sushma Kavikondala, Katrin Haeussler, Xuan Wang, Anne Spellman, Mary T. Bausch-Jurken, Pawana Sharma, Mohammadreza Amiri, Anna Krivelyova, Sonam Vats, Maria Nassim, Nitendra Kumar, Nicolas Van de Velde
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	BNT162b2 Cellular immunity COVID-19 Immunocompromised mRNA-1273 mRNA vaccine Infectious and parasitic diseases RC109-216
Zdroj:	Infectious Diseases and Therapy, Vol 13, Iss 7, Pp 1419-1438 (2024)
Druh dokumentu:	article
ISSN:	2193-8229 2193-6382
DOI:	10.1007/s40121-024-00987-2
Popis:	Abstract Introduction Immunocompromised (IC) patients mount poor immune responses to vaccination. Higher-dose coronavirus disease 2019 (COVID-19) vaccines may offer increased immunogenicity. Methods A pairwise meta-analysis of 98 studies reporting comparisons of mRNA-1273 (50 or 100 mcg/dose) and BNT162b2 (30 mcg/dose) in IC adults was performed. Outcomes were seroconversion, total and neutralizing antibody titers, and cellular immune responses. Results mRNA-1273 was associated with a significantly higher seroconversion likelihood [relative risk, 1.11 (95% CI, 1.08, 1.14); P
Databáze:	Directory of Open Access Journals
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