The effect of synovial fluid as a natural source of hyaluronic acid on limberg flap and elliptical rotation flap healing: a comparative study of full-thickness excisional dermal wounds in mice

Autor: Hasan ÇANTAY, Uğur AYDIN, Turgut ANUK, Emin KARAKURT, Uğur YILDIZ, Hilmi NUHOĞLU
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Kafkas Universitesi Veteriner Fakültesi Dergisi, Vol 27, Iss 3, Pp 355-361 (2021)
Druh dokumentu: article
ISSN: 1309-2251
DOI: 10.9775/kvfd.2021.25525
Popis: The purpose of this study was to investigate the effi cacy of synovial fl uid (SF) as a source of hyaluronic acid (HA) on Limberg and Elliptical rotation fl ap healing. In this study conducted on 24 male Mus musculus mice, the animals were divided into 2 main groups. Group 1 (n = 12): Limbergfl ap group; Group 2 (n = 12) Elliptical rotation fl ap group. 6 of the animals in Group 1 and Group 2 were assigned as the Flap (Control) Group, and 6 as the Flap + SF Group. In SF subgroups of animals in each group, 1 mL SF was injected into the operation area in addition to the fl ap surgical procedure. The groups were compared in terms of epithelialization, angiogenesis, neutrophil leukocyte infiltration and fibroblast activity, and the eff ect of SF on the infl ammation and wound healing was evaluated. It was observed that epithelization was completed in all animals in the groups which were administered compared to the other groups, and there was a statistically significant diff erence (P
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