Survival and glycemic control in patients with co-existing squamous cell carcinoma and diabetes mellitus
| Autor: | Sophia A Ederaine, Johanny Lopez Dominguez, Jamison A Harvey, Aaron R Mangold, Curtiss B Cook, Heidi Kosiorek, Matthew Buras, Kyle Coppola, Nina J Karlin |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Future Science OA, Vol 7, Iss 5 (2021) |
| Druh dokumentu: | article |
| ISSN: | 2056-5623 07859856 |
| DOI: | 10.2144/fsoa-2020-0150 |
| Popis: | Aim: This study examined the impact of diabetes mellitus (DM) on survival in squamous cell carcinoma (SCC) patients, and the impact of SCC on glycemic control. Materials & methods: Patients with newly diagnosed SCC with and without DM were matched 1:1 (2007–2017). Overall survival and recurrence-free survival were estimated using the Kaplan–Meier method. Hemoglobin A1c (HbA1c) and glucose level during the year following cancer diagnosis were compared using mixed models. Results: HbA1c decreased over time in DM patients (p = 0.04). The 5-year overall survival was 61% in DM patients, compared with 78% in patients without DM (p = 0.004). Conclusion: The presence of co-existing DM adversely impacted survival in patients with SCC. SCC did not affect glycemic control. |
| Databáze: | Directory of Open Access Journals |
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