| Autor: |
Nurina Febriyanti Ayuningtyas, Meircurius Dwi Condro Surboyo, Diah Savitri Ernawati, Adiastuti Endah Parmadiati, Hening Tuti Hendarti, Fatma Yasmin Mahdani, Saka Winias, Fitriatuz Zakia, Indira Arella Harianto |
| Jazyk: |
English<br />Spanish; Castilian |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
Journal of Pharmacy & Pharmacognosy Research, Vol 8, Iss 6, Pp 549-557 (2020) |
| Druh dokumentu: |
article |
| ISSN: |
0719-4250 |
| Popis: |
Context: Liquid smoke coconut shell (LS-CS) contains phenolic compounds that are able to promote wound healing by interfering with the inflammation phase of wound healing. The homeostatic mechanism that decreases the inflammation releases a growth factor that enhances proliferation by increasing fibroblast growth factor-2 (FGF-2), vascular endothelial growth factor (VEGF) expression and fibroblast proliferation. Aims: To analyze the role of LS-CS in the proliferation phase of oral traumatic ulcer healing by analyzing fibroblast numbers and FGF-2 and VEGF expressions. Methods: Oral traumatic ulcers were induced in diabetes mellitus Wistar rats via an alloxan injection. A traumatic ulcer as long as 10 mm was made in the inferior fornix incisive labial area. The oral traumatic ulcer was then topically treated with LS-CS using a dose of 20 μL/ 20 g body weight once daily for three, five and seven days. The fibroblast number of the oral traumatic ulcers’ tissue was then analyzed using hematoxylin-eosin, and the FGF-2 and VEGF expression were analyzed via immunohistochemistry staining. The difference in fibroblast numbers and FGF-2 and VEGF expressions were analyzed by one-way ANOVA and post hoc tests with a significance of p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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