Cefiderocol Efficacy in a Real-Life Setting: Single-Centre Retrospective Study
| Autor: | Gabriele Palermo, Alice Annalisa Medaglia, Luca Pipitò, Raffaella Rubino, Manuela Costantini, Salvatore Accomando, Giovanni Maurizio Giammanco, Antonio Cascio |
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| Jazyk: | angličtina |
| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Antibiotics, Vol 12, Iss 4, p 746 (2023) |
| Druh dokumentu: | article |
| ISSN: | 12040746 2079-6382 23905085 |
| DOI: | 10.3390/antibiotics12040746 |
| Popis: | The current carbapenem-resistant gram-negative bacteria (CR-GN) treatment guidelines lack strong evidence about cefiderocol (CFD) efficacy against CR-GN, especially CRAB. The study’s purpose is to evaluate the effectiveness of CFD in a real-life setting. We made a single-center retrospective study of 41 patients who received CFD in our hospital for several CR-GN infections. Bloodstream infections (BSI) affected 43.9% (18/41) of patients, while CRAB affected 75.6% (31/41) of isolated CR-GN patients. Thirty-days (30-D) all-causes mortality affected 36.6% (15/41) of patients, while end-of-treatment (EOT) clinical cure affected 56.1% (23/41). Finally, microbiological eradication at EOT affected 56.1% (23/41) of patients. Univariate and multivariate analysis showed that septic shock is an independent factor associated with mortality. Subgroup analyses showed no difference in CFD effectiveness between monotherapy and combination therapy. |
| Databáze: | Directory of Open Access Journals |
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