Association between Glycosylated Hemoglobin Levels and Vaccine Preventable Diseases: A Systematic Review
| Autor: | Elda De Vita, Federica Limongi, Nicola Veronese, Francesco Di Gennaro, Annalisa Saracino, Stefania Maggi |
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| Jazyk: | angličtina |
| Rok vydání: | 2024 |
| Předmět: | |
| Zdroj: | Diseases, Vol 12, Iss 8, p 187 (2024) |
| Druh dokumentu: | article |
| ISSN: | 12080187 2079-9721 |
| DOI: | 10.3390/diseases12080187 |
| Popis: | People with diabetes are at higher risk of serious complications from many vaccine-preventable diseases (VPDs). Some studies have highlighted the potential impact of glycosylated hemoglobin levels (HbA1c), but no systematic review has synthesized these findings. Of the 823 identified studies, 3 were included, for a total of 705,349 participants. Regarding the incidence of herpes zoster (HZ), one study found that higher HbA1c levels at the baseline (>10.3%) were associated with a significantly higher risk of HZ of 44%, compared to those with a good HbA1c control (6.7%). On the contrary, the second one reported that when compared to the reference group (HbA1c of 5.0–6.4%), participants with a HbA1c less than 5.0% were at higher risk of HZ of 63%, whilst participants with a HBA1c more than 9.5% had a similar risk. Finally, the third study observed that diabetes, defined using a value of HbA1c more than 7.5%, was associated with an increased risk of mortality in men with COVID-19. In conclusion, both high and low HBA1c levels appear to be associated with a higher risk of HZ. Regarding COVID-19, a value of HbA1c more than 7.5% was associated with a higher risk of death in COVID-19, but only in men. |
| Databáze: | Directory of Open Access Journals |
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