Cytosolic and mitochondrial Ca2+ signaling in procoagulant platelets
| Autor: | Sarah L. Millington-Burgess, Matthew T. Harper |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Platelets, Vol 32, Iss 7, Pp 855-862 (2021) |
| Druh dokumentu: | article |
| ISSN: | 0953-7104 1369-1635 09537104 42947278 |
| DOI: | 10.1080/09537104.2021.1881951 |
| Popis: | Platelets are the major cellular contributor to arterial thrombosis. However, activated platelets form two distinct subpopulations during thrombosis. Pro-aggregatory platelets aggregate to form the main body of the thrombus. In contrast, procoagulant platelets expose phosphatidylserine on their outer surface and promote thrombin generation. This apparently all-or-nothing segregation into subpopulations indicates that, during activation, platelets commit to becoming procoagulant or pro-aggregatory. Although the signaling pathways that control this commitment are not understood, distinct cytosolic and mitochondrial Ca2+ signals in different subpopulations are likely to be central. In this review, we discuss how these Ca2+ signals control procoagulant platelet formation and whether this process can be targeted pharmacologically to prevent arterial thrombosis. |
| Databáze: | Directory of Open Access Journals |
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