Management of Allogeneic Stem Cell Transplantation for High-Risk AML following SARS-CoV-2 Associated Pancytopenia with Marked Bone Marrow Biopsy Alterations

Autor: Maria Kaparou, Zbigniew Rudzki, Hannah Giles, Vidhya Murthy, Swathy Srinath, Rebecca Lloyd, Maria Zahid Ahmed, Beena Salhan, Saleena Chauhan, Bhuvan Kishore, Richard Lovell, Claire Horgan, Shankara Paneesha, Evgenia Xenou, Anand Lokare, Joanne Ewing, Hansini Dassanayake, Emmanouil Nikolousis, Alexandros Kanellopoulos
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Case Reports in Hematology, Vol 2021 (2021)
Druh dokumentu: article
ISSN: 2090-6560
2090-6579
DOI: 10.1155/2021/8843063
Popis: The present study describes a patient aged 70 with very high-risk AML who successfully received a nonmyeloablative matched unrelated donor allograft shortly following SARS-CoV-2 infection, which manifested with mild cough, interstitial abnormalities on chest CT, and pancytopenia with profound bone marrow biopsy histological alterations. In parallel, our study provides bone marrow biopsy data in a series of contemporary patients with serious haematological diseases who had a bone marrow biopsy performed within two weeks of PCR confirmation of SARS-CoV-2 infection. This study is notable because there are no published data describing the bone marrow biopsy changes observed in patients with haematological malignancies and SARS-CoV-2 infection. Finally, it is suggested that nonmyeloablative hematopoietic stem cell transplantation for very high-risk haematological malignancies can be successfully performed following recovery from SARS-CoV-2 infection.
Databáze: Directory of Open Access Journals
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