| Autor: |
Zi-Mo Chen, Jing-Lin Mo, Kai-Xuan Yang, Ying-Yu Jiang, Chun-Juan Wang, Xin Yang, Yong Jiang, Xia Meng, Jie Xu, Hao Li, Li-Ping Liu, Yi-Long Wang, Xing-Quan Zhao, Yong-Jun Wang, Hong-Qiu Gu, Zi-Xiao Li |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
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| Zdroj: |
The Innovation, Vol 5, Iss 6, Pp 100713- (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2666-6758 |
| DOI: |
10.1016/j.xinn.2024.100713 |
| Popis: |
Although essential for cardiovascular therapy, the pleiotropic effects of statins on ischemic stroke lack clinical evidence. This study examined the effects of statins beyond low-density lipoprotein cholesterol (LDL-C) levels on mortality and stroke severity. A total of 825,874 patients with ischemic stroke were included in this study, of whom 125,650 statin users were 1:1 matched with non-users based on their LDL-C levels (±0.05 mmol/L), forming the LDL-C-matched cohort. Associations between preceding statin treatment, in-hospital mortality, and stroke severity (National Institutes of Health Stroke Scale score ≥16) were estimated by multivariate and conditional logistic regression models in overall cohort and LDL-C-matched cohort, respectively. The overall statin effects reduced in-hospital mortality (odds ratio [OR]: 0.72, 95% confidence interval [CI]: 0.65–0.79, p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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