De novo hepatocellular carcinoma occurrence in hepatitis C cirrhotics treated with direct-acting antiviral agents

Autor:	Gabriela Kuftinec, Thomas Loehfelm, Michael Corwin, Blythe Durbin-Johnson, MarieChristi Candido, Rebecca Hluhanich, Souvik Sarkar
Jazyk:	angličtina
Rok vydání:	2018
Předmět:	cirrhosis de novo HCC direct-acting antivirals hepatitis C virus hepatocellular carcinoma interferon Diseases of the digestive system. Gastroenterology RC799-869 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Zdroj:	Hepatic Oncology, Vol 5, Iss 1 (2018)
Druh dokumentu:	article
ISSN:	2045-0931 2045-0923
DOI:	10.2217/hep-2018-0003
Popis:	Aim: Recent studies raise concerns for higher incidence of hepatocellular carcinoma (HCC) after direct-acting antiviral therapy for hepatitis C virus (HCV). Methods: In this study, using analysis of liver imaging pre- and post-DAA treatment, we queried new occurrence or ‘de novo’ of HCC in patients with HCV-cirrhosis treated with DAAs. Of 150 patients who met study criteria, 7 (4.7%; 95% CI: 2.1–9.5%) patients developed de novo HCC which did not differ from historical rates of 3% (p = 0.22). Results: Notably, patients with decompensated cirrhosis had significantly higher rate of de novo HCC (9.3%; 95% CI: 3.12–22.2%; p = 0.04). Conclusion: Our data support the need for continued surveillance for HCC in HCV cirrhotics even after successful therapy.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/5ab1c1e396f545b5b5c49f9bf49c2b1e Zobrazit plný text záznamu View record in DOAJ