| Autor: |
P.A. Tsaku, Y.B. Ngwai, G.R.I. Pennap, D. Ishaleku, T. Ibrahim, I.H. Nkene, R.H. Abimiku |
| Jazyk: |
angličtina |
| Rok vydání: |
2019 |
| Předmět: |
|
| Zdroj: |
Heliyon, Vol 5, Iss 8, Pp e02177- (2019) |
| Druh dokumentu: |
article |
| ISSN: |
2405-8440 |
| DOI: |
10.1016/j.heliyon.2019.e02177 |
| Popis: |
Serious clinical concern has been raised globally over the continual evolution of pathogenic microorganisms that are resistant to several chemotherapeutic agents, especially the beta-lactam antibiotics. This study investigated ESBL-production in Escherichia coli isolated from door handles in Nasarawa State University, Keffi-Nigeria. A total of 200 door handles were sampled and 34 (17.0%) E. coli isolates were identified. The bacterial resistance profile to tested antibiotics was: tetracycline 31 (91.18%), cotrimoxazole, ceftazidime, and augmentin with 28 (82.35%). Streptomycin and ampicillin had 26 (76.47%), while ciprofloxacin, chloramphenicol, ceftriaxone, and gentamicin had 16 (47.06%), 14 (41.18%), 12 (35.29%) and 7 (20.59%) resistance profile respectively. Multiple antibiotics resistance index (MARI) ≥ 0.3 was recorded in 33 (97.06%) of the isolates. A total of 23 resistant phenotypes were observed in this study. The most common resistant phenotype was AMP-AUG-CAZ-CRO-S-CIP-SXT-TE-C with 4 appearances. Fourteen (14) of the isolates were Multidrug resistant (MDR), while 9 were extensively resistant (XDR) isolates. Fifteen (15) ESBL-producers were identified out of which blaTEM was identified in 7 of the isolates, while 10 were carriers of blaSHV, and blaCTX-M gene was not detected in any of the test isolates. This study recommends prompt action by all stakeholders in public health to prevent a potential disease burden from a superbug. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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