Effects of tyrosine kinase inhibitor-masitinib mesylate on canine mammary tumour cell lines

Autor: Ustun-Alkan Fulya, Bakırel Tülay, Üstüner Oya, Anlas Ceren, Cinar Suzan, Yıldırım Funda, Gürel Aydın
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Journal of Veterinary Research, Vol 65, Iss 3, Pp 351-359 (2021)
Druh dokumentu: article
ISSN: 2450-8608
DOI: 10.2478/jvetres-2021-042
Popis: Masitinib mesylate, a selective tyrosine kinase inhibitor of the c-KIT receptor, is used for the treatment of mast cell tumours in dogs. Masitinib has previously been investigated in various cancers; however, its potential anticancer effect in canine mammary tumours (CMTs) is unknown. In the present paper, we investigated the antiproliferative effect of masitinib in CMT cells and its possible mechanisms of action.
Databáze: Directory of Open Access Journals