| Autor: |
Chen-Hua Liu, Yih-Sharng Chen, Meng-Kun Tsai, Sheoi-Shen Wang, Chih-Yuan Lee, Chuan-I Tsao, Chun-Jen Liu, Tung-Hung Su, Tai-Chung Tseng, Shang-Chin Huang, Jo-Hsuan Wu, Pei-Jer Chen, Jia-Horng Kao |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
Journal of the Formosan Medical Association, Vol 122, Iss 8, Pp 800-804 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
0929-6646 |
| DOI: |
10.1016/j.jfma.2023.03.004 |
| Popis: |
Data are limited regarding the long-term durability of sustained virologic response (SVR) in solid organ transplant recipients who achieve SVR12 with direct-acting antivirals (DAAs) for hepatitis C virus (HCV). We reported the virologic outcomes in 42 recipients who received DAAs for acute or chronic HCV infection after heart, liver, and kidney transplantation. After achieving SVR12, all recipients received HCV RNA surveys at SVR24, and biannually until the last visit. If HCV viremia was detected during the follow-up period, direct sequencing and phylogenetic analysis were performed to confirm late relapse or reinfection. Sixteen (38.1%), 11 (26.2%), and 15 (35.7%) patients underwent heart, liver and, kidney transplantation. Thirty-eight (90.5%) received sofosbuvir (SOF)-based DAAs. No recipients had late relapse or reinfection after a median (range) of post-SVR12 follow-up 4.0 (1.0–6.0) years. We demonstrate that the durability of SVR in solid organ transplant recipients is excellent once SVR12 is achieved with DAAs. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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