| Autor: |
Gerges Abdelsayed, Danish Ali, Andrew Malone, Jemil Saidi, Manoj Myneni, Keshava Rajagopal, Faisal H. Cheema, Aamir Hameed |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Applications in Engineering Science, Vol 12, Iss , Pp 100115- (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2666-4968 |
| DOI: |
10.1016/j.apples.2022.100115 |
| Popis: |
Cardiovascular diseases are the leading cause of morbidity and mortality and a huge economic burden on the healthcare system globally. Both pharmacological and device based treatment options have emerged over the years, however, it is still a ‘holy grail’ to effectively treat some cardiovascular conditions, for example, heart failure. Any treatment option whether it is drug therapy or a device therapy, has to go through a rigorous regulatory approval process. This requires robust pre-clinical research and clinical trial results. In order to proceed to the clinical trials, pre-clinical research is very important and may take methodologies which are at the interface of biology and engineering, for example, in-vitro, ex-vivo and in-vivo models. This paper focusses on the 2D and 3D in-vitro models to mimic the pathophysiology of a specific cardiovascular disease and their advantages and limitations. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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