| Autor: |
N. Scher, S. Bonvalot, C. Le Tourneau, E. Chajon, C. Verry, J. Thariat, V. Calugaru |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
Biotechnology Reports, Vol 28, Iss , Pp e00548- (2020) |
| Druh dokumentu: |
article |
| ISSN: |
2215-017X |
| DOI: |
10.1016/j.btre.2020.e00548 |
| Popis: |
Purpose: Clinical evidence of the radiation-enhancing effects of nanoparticles has emerged. Materials and methods: We searched the literature in English and French on PubMed up to October 2019. The search term was “nanoparticle” AND “radiotherapy”, yielding 1270 results. Results: The two main NP used in clinical trials were hafnium oxide and gadolinium involving a total of 229 patients. Hafnium oxide NP were used in three phase 1/2 trials on sarcoma, head and neck squamous cell carcinoma or liver cancer and one phase 2/3 trial. There are six ongoing phase 1/2 clinical trials to evaluate the combination of gadolinium-based NP and RT for the treatment of brain metastases and cervical cancer. Conclusion: So far, intratumoral hafnium oxide nanoparticles were safe and improved efficacy in locally advanced sarcoma. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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