Intestinal Microbiota as Modulators of the Immune System and Neuroimmune System: Impact on the Host Health and Homeostasis
| Autor: | Carlos Magno da Costa Maranduba, Sandra Bertelli Ribeiro De Castro, Gustavo Torres de Souza, Cristiano Rossato, Francisco Carlos da Guia, Maria Anete Santana Valente, João Vitor Paes Rettore, Claudinéia Pereira Maranduba, Camila Maurmann de Souza, Antônio Márcio Resende do Carmo, Gilson Costa Macedo, Fernando de Sá Silva |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: | |
| Zdroj: | Journal of Immunology Research, Vol 2015 (2015) |
| Druh dokumentu: | article |
| ISSN: | 2314-8861 2314-7156 |
| DOI: | 10.1155/2015/931574 |
| Popis: | Many immune-based intestinal disorders, such as ulcerative colitis and Crohn’s disease, as well as other illnesses, may have the intestines as an initial cause or aggravator in the development of diseases, even apparently not correlating directly to the intestine. Diabetes, obesity, multiple sclerosis, depression, and anxiety are examples of other illnesses discussed in the literature. In parallel, importance of the gut microbiota in intestinal homeostasis and immunologic conflict between tolerance towards commensal microorganisms and combat of pathogens is well known. Recent researches show that the immune system, when altered by the gut microbiota, influences the state in which these diseases are presented in the patient directly and indirectly. At the present moment, a considerable number of investigations about this subject have been performed and published. However, due to difficulties on correlating information, several speculations and hypotheses are generated. Thus, the present review aims at bringing together how these interactions work—gut microbiota, immune system, and their influence in the neuroimmune system. |
| Databáze: | Directory of Open Access Journals |
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