| Autor: |
Rebecca Martínez-Moreno, Alexandra Pérez-Serra, Elisabet Selga, David Carreras, Begoña Aran, Bernd Kuebler, Fabiana S. Scornik, Guillermo J. Pérez, Ramon Brugada |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
Stem Cell Research, Vol 73, Iss , Pp 103239- (2023) |
| Druh dokumentu: |
article |
| ISSN: |
1873-5061 |
| DOI: |
10.1016/j.scr.2023.103239 |
| Popis: |
Tissue-specific cells differentiated from patient-derived human induced pluripotent stem cells (hiPSC) are a relevant cellular model to study several diseases. We obtained a hiPSC line from skin fibroblasts of a patient affected by familial atrial fibrillation by nucleofection of non-integrating episomal vectors. The resulting hiPSC line displays a normal karyotype, expresses pluripotency surface markers and pluripotency genes, and differentiates into cells of the 3 germ layers. Therefore, it represents a reliable model to study the disease in a physiologically relevant cellular environment. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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