| Autor: |
Xin-Jing Zhao, Bin Ji, Chao Shang, De-Yu Li, Sheng Zhang, Hong-Jing Gu, Hong-Hong Peng, Cheng Qian, Cui-Ling Zhang, Chao Shi, Yuan Shen, Jin-Jin Chen, Qiang Xu, Chen-Long Lv, Bao-Gui Jiang, Hui Wang, Xiao Li, Guo-Lin Wang, Li-Qun Fang |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
iScience, Vol 27, Iss 7, Pp 110283- (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2589-0042 |
| DOI: |
10.1016/j.isci.2024.110283 |
| Popis: |
Summary: The emergence of novel Omicron subvariants has raised concerns regarding the efficacy of immunity induced by prior Omicron subvariants breakthrough infection (BTI) or reinfection against current circulating Omicron subvariants. Here, we prospectively investigated the durability of antibody and T cell responses in individuals post Omicron BA.2.2 BTI, with or without subsequent Omicron BA.5 reinfection. Our findings reveal that the emerging Omicron subvariants, including CH.1.1, XBB, and JN.1, exhibit extensive immune evasion induced by previous infections. Notably, the level of IgG and neutralizing antibodies were found to correlate with subsequent Omicron BA.5 reinfection. Fortunately, T cell responses recognizing both Omicron BA.2 and CH.1.1 peptides were observed. Furthermore, Omicron BA.5 reinfection may alleviate immune imprinting induced by WT-vaccination, bolster virus-specific ICS+ T cell responses, and promote the phenotypic differentiation of virus-specific memory CD8+ T cells. Antigen-updated or T cell-conserved vaccines are needed to control the transmission of diverse emerging SARS-CoV-2 variants. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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