| Autor: |
Scott Dillon, Karla Suchacki, Shun‐Neng Hsu, Louise A Stephen, Rongling Wang, William P Cawthorn, Alan J Stewart, Fabio Nudelman, Nicholas M Morton, Colin Farquharson |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
JBMR Plus, Vol 5, Iss 2, Pp n/a-n/a (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2473-4039 |
| DOI: |
10.1002/jbm4.10439 |
| Popis: |
ABSTRACT Biomineralization is a fundamental process key to the development of the skeleton. The phosphatase orphan phosphatase 1 (PHOSPHO1), which likely functions within extracellular matrix vesicles, has emerged as a critical regulator of biomineralization. However, the biochemical pathways that generate intravesicular PHOSPHO1 substrates are currently unknown. We hypothesized that the enzyme ectonucleotide pyrophosphatase/phosphodiesterase 6 (ENPP6) is an upstream source of the PHOSPHO1 substrate. To test this, we characterized skeletal phenotypes of mice homozygous for a targeted deletion of Enpp6 (Enpp6−/−). Micro‐computed tomography of the trabecular compartment revealed transient hypomineralization in Enpp6−/− tibias (p 0.01) and osteoid surface (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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