Clinical stability after compassionate use of intranasal esketamine in treatment-resistant depression
| Autor: | D. Hernandez Huerta, A. De Santiago Diaz, C. Rodriguez Gomez-Carreño, M.A. Abril Garcia, F. Toledo Romero, A. Guerrero Morcillo, C.J. Martinez Pastor, M. Vega Piñero |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | European Psychiatry, Vol 65, Pp S298-S299 (2022) |
| Druh dokumentu: | article |
| ISSN: | 0924-9338 1778-3585 |
| DOI: | 10.1192/j.eurpsy.2022.762 |
| Popis: | Introduction The compassionate use of intranasal esketamine is approved in Spain for treatment-resistant depression (TRD). Objectives The objective of the study is to assess the clinical stability in the medium-term follow-up of patients with TRD after esketamine use. Methods Descriptive, retrospective and multicenter study carried out in Spain. Patients with TRD who had received esketamine treatment, and for whom there were clinical data of subsequent evolution, were included. The scores on the MADRS and Hamilton scales were changed into scores on the CGI scale according to the studies by Leucht et al. The Student’s t test was performed to assess differences in the CGI. Results Eleven patients were included: 72.7% were women and the mean age was 56 (SD: 12.9). The maximum dose of esketamine used was 84mg in 63.7%. The onset of antidepressant action was observed from the 1st dose in 72.6% of the patients. The mean time in treatment was 6.6 months (SD: 2.3) and 90.9% reached remission criteria. After 7.4 months (SD: 3.0) from the end of the treatment, 90.9% remained in remission and without visits to the emergency room or hospitalization for psychiatric reasons. The mean baseline score on the CGI-SI was 5.7 points, at the end of the treatment was 1.2 points and after longitudinal follow-up it was 1. Statistically significant differences were observed (p |
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