Synthesis of two novel C-19 analogues of (±)-alstoscholarisine A
| Autor: | Bihelović Filip, Ferjančić Zorana, Jončev Zlatko |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: | |
| Zdroj: | Journal of the Serbian Chemical Society, Vol 84, Iss 9, Pp 935-941 (2019) |
| Druh dokumentu: | article |
| ISSN: | 0352-5139 1820-7421 |
| DOI: | 10.2298/JSC190212026B |
| Popis: | Two new analogues of alstoscholarisine A, containing a phenyl or butyl substituent at the C-19 position, have been prepared in racemic form from the known skatole derivative. The syntheses of these compounds were accomplished in 13 steps, with a late-stage formation of the C-19 stereocenter. These derivatives are expected to have significantly changed biological activity, compared to alstoscholarisine A – a potent neuroactive natural product. [Project of the Serbian Ministry of Education, Science and Technological Development, Grant no. 172027] |
| Databáze: | Directory of Open Access Journals |
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