Fabrication of micro-patterned titanium dioxide nanotubes thin film and its biocompatibility
| Autor: | Li-jie Xiang, Chun-hui Li, Ping Yang, Jing-an Li, Nan Huang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
titanium compounds
nanobiotechnology cellular biophysics nanofabrication nanotubes thin films micropatterned titanium dioxide nanotubes thin film biocompatibility biomaterials surface anticoagulant smooth muscle proliferation proendothelialisation photolithography endothelial cells growth cell function TiO2 Engineering (General). Civil engineering (General) TA1-2040 |
| Zdroj: | The Journal of Engineering (2014) |
| Druh dokumentu: | article |
| ISSN: | 2051-3305 |
| DOI: | 10.1049/joe.2014.0274 |
| Popis: | In this study, in order to obtain a novel biomaterials surface which possesses the functions of an anticoagulant, inhibiting smooth muscle proliferation and pro-endothelialisation simultaneously, a micro-patterned titanium dioxide (TiO(2))-nanotubes (P-TiO(2)-nanotubes) thin film was prepared on titanium (Ti) surface by photolithography combining with anodising method. The authors found that the P-TiO(2)-nanotubes could reduce platelet attachment and conformational change of fibrinogen (FGN) as well as promoting endothelial cells (ECs) growth compared with the TiO(2)-nanotubes. Notably, P-TiO(2)-nanotubes could significantly reduce smooth muscle cells (SMCs) proliferation compared with TiO(2)-nanotubes and TiO(2), and the ECs and SMCs cultured on the P-TiO(2)-nanotubes thin film were elongated, which was suggested to be beneficial for maintaining the cell function. Therefore it is suggested that the P-TiO(2)-nanotubes thin film can contribute more to biocompatible functions of regulating and coordinating the behaviour of platelets, ECs and SMCs. |
| Databáze: | Directory of Open Access Journals |
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