A Case of COVID-19-Associated Pediatric Multisystem Inflammatory Syndrome in Shock Managed by Cytokine Filtration

Autor: Priyanka Lalwani, Subashini Baskaran, Diego Arango Uribe, Anil Ramaiah, Aqdas Saqib, Mohammed ElMesserey, Emad M. Fathi, Yuichi Tabata, Christoph Fink, Marco Pallavidino
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Case Reports in Pediatrics, Vol 2022 (2022)
Druh dokumentu: article
ISSN: 2090-6811
DOI: 10.1155/2022/3373289
Popis: Multisystem inflammatory syndrome in children (MIS-C) after COVID-19 has been recognized as a complication arising due to cytokine storm. Several management strategies including intravenous immunoglobulin and immunomodulators have been reported. This case report highlights the use of a cytokine filter (oXiris®) in the management of MIS-C. Cytokine filters eliminate cytokines and reduce the demand for vasopressors in patients with other inflammatory conditions. A 7-year-old child with prolonged fever, vomiting, hypotension, elevated inflammatory mediators, and dilatation of coronary arteries on echocardiography was found to have positive SARS-CoV-2 IgG and PCR. He was diagnosed as MIS-C and was managed in the pediatric intensive care unit. He required ventilatory support, vasopressors, and continuous renal replacement therapy (CRRT) with a cytokine filter. He showed marked improvement within 24 hours of initiating CRRT. Cytokine filters may have a potential role in the management of severely ill children due to MIS-C. To our knowledge, this is the first report of successful use of the oXiris® membrane in MIS-C. However, further case series and controlled trials are needed to establish its use in this condition.
Databáze: Directory of Open Access Journals
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