| Autor: |
Xu Zhang, Scott R. Solomon, Connie Sizemore |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
BMC Medical Research Methodology, Vol 22, Iss 1, Pp 1-10 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
1471-2288 |
| DOI: |
10.1186/s12874-022-01771-x |
| Popis: |
Abstract This paper provides the methodologies of a new summary curve that measures the dynamic outcome following allogenic hematopoietic cell transplantation. This new summary curve computes the probabilities that a patient is alive in remission and free of severe-to-moderate chronic graft-versus-host disease (GVHD) over time. The probability is called Current chronic GVHD-free, Relapse-Free Survival (CGRFS). Based on a multistate model depicting the possible states that a patient may experience after transplant, CGRFS can be formulated as a linear combination of five survival functions. This method is known as the model-free approach. In this paper we provide the inferences of the model-free approach, including estimation of CGRFS, precision evaluation and comparison of CGRFS between two independent samples. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
|
Nepřihlášeným uživatelům se plný text nezobrazuje |
K zobrazení výsledku je třeba se přihlásit.
|
