Drug induced erythema multiforme: Reporting 2 cases

Autor: Kamala Rawson, R Usha Rani, Sonia Susan, Gigi Roy, Neha Gupta
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: Journal of Indian Academy of Oral Medicine and Radiology, Vol 30, Iss 3, Pp 306-309 (2018)
Druh dokumentu: article
ISSN: 0972-1363
DOI: 10.4103/jiaomr.jiaomr_73_18
Popis: Erythema multiforme (EM) is a rare, acute, inflammatory mucocutaneous condition caused by a hypersensitivity reaction with the appearance of cytotoxic T lymphocytes in the epithelium that induce apoptosis in keratinocytes, which leads to satellite cell necrosis. Reactions to drugs are quite common and are generally mild, hence not reported. However, occasionally life-threatening reactions including EM major (Steven–Johnson syndrome) and toxic epidermal necrolysis may occur. A wide spectrum of drugs can sometimes give rise to EM. We report two cases of EM following administration of non-steroidal anti-inflammatory drugs.
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