Autor: |
Niccolo’ Rossi, Elbay Aliyev, Alessia Visconti, Ammira S. A. Akil, Najeeb Syed, Waleed Aamer, Sujitha S. Padmajeya, Mario Falchi, Khalid A. Fakhro |
Jazyk: |
angličtina |
Rok vydání: |
2021 |
Předmět: |
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Zdroj: |
npj Genomic Medicine, Vol 6, Iss 1, Pp 1-9 (2021) |
Druh dokumentu: |
article |
ISSN: |
2056-7944 |
DOI: |
10.1038/s41525-021-00170-3 |
Popis: |
Abstract Studies assessing the impact of amylase genes copy number (CN) on adiposity report conflicting findings in different global populations, likely reflecting the impact of ancestral and ethnic-specific environment and lifestyle on selection at the amylase loci. Here, we leverage population size and detailed adiposity measures from a large population biobank to resolve confounding effects and determine the relationship between salivary (AMY1) and pancreatic (AMY2A) amylase genes CN and adiposity in 2935 Qatari individuals who underwent whole-genome sequencing (WGS) as part of the Qatar Genome Programme. We observe a negative association between AMY1 CNs and trunk fat percentage in the Qatari population (P = 7.50 × 10−3) and show that Qataris of Arab descent have significantly lower CN at AMY1 (P = 1.32 × 10−10) as well as less favorable adiposity and metabolic profiles (P |
Databáze: |
Directory of Open Access Journals |
Externí odkaz: |
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