| Autor: |
Adele A Rodrigues, Tatiana M Clemente, Marlus A Dos Santos, Fabrício C Machado, Rafael G B Gomes, Heline Hellen T Moreira, Mário C Cruz, Paula C Brígido, Paulo C F Dos Santos, Flávia A Martins, Diana Bahia, Juliana T Maricato, Luiz M R Janini, Eduardo H Reboredo, Renato A Mortara, Claudio V da Silva |
| Jazyk: |
angličtina |
| Rok vydání: |
2012 |
| Předmět: |
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| Zdroj: |
PLoS ONE, Vol 7, Iss 12, p e51384 (2012) |
| Druh dokumentu: |
article |
| ISSN: |
1932-6203 |
| DOI: |
10.1371/journal.pone.0051384 |
| Popis: |
BACKGROUND: P21 is a secreted protein expressed in all developmental stages of Trypanosoma cruzi. The aim of this study was to determine the effect of the recombinant protein based on P21 (P21-His(6)) on inflammatory macrophages during phagocytosis. FINDINGS: Our results showed that P21-His(6) acts as a phagocytosis inducer by binding to CXCR4 chemokine receptor and activating actin polymerization in a way dependent onthe PI3-kinase signaling pathway. CONCLUSIONS: Thus, our results shed light on the notion that native P21 is a component related to T. cruzi evasion from the immune response and that CXCR4 may be involved in phagocytosis. P21-His(6) represents an important experimental control tool to study phagocytosis signaling pathways of different intracellular parasites and particles. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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