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Objective: To test if arterial stiffness (AS) can be modulated by the autonomic nervous system (ANS) independently of blood pressure (BP) in hypertensive patients. Material and methods: AS was measured by carotid-femoral pulse wave velocity (cfPWV) using the SphygmoCor device (AtCor Medical, Australia). Mean arterial pressure (MAP) was obtained by pulse-wave analysis of the radial artery and ANS activity was estimated by heart rate variability (HRV) as log-ratio of low-frequency/high-frequency heart rate components (Schiller Medilog AR12plus, United States) in hypertensive subjects (n = 43, 17 female, mean ± SD age 45 ± 13 years, brachial BP 145 ± 17/87 ± 10 mmHg) at rest. All measurements were subsequently repeated during supervised device-guided paced breathing (DGB) and reduction of cardiac pre-load by lower limb venous occlusion (LVO). These interventions, which are known to decrease and increase sympathetic activity, were performed in random order. Results: DGB reduced HRV by 0.14 [0.07, 0.20] (Mean [95% confidence intervals]) and LVO increased HRV by 0.13 [0.08, 0.18] (both P |
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