Access to new medications for the treatment of drug-resistant tuberculosis: Patient, provider and community perspectives

Autor: Erica Lessem, Helen Cox, Colleen Daniels, Jennifer Furin, Lindsay McKenna, Carole D. Mitnick, Thato Mosidi, Caitlin Reed, Barbara Seaworth, Jonathan Stillo, Phumeza Tisile, Dalene von Delft
Jazyk: angličtina
Rok vydání: 2015
Předmět:
Zdroj: International Journal of Infectious Diseases, Vol 32, Iss C, Pp 56-60 (2015)
Druh dokumentu: article
ISSN: 1201-9712
1878-3511
DOI: 10.1016/j.ijid.2014.12.012
Popis: Multidrug-resistant tuberculosis (MDR-TB) is on the rise, and is difficult to treat. The approval of two new drugs, bedaquiline and delamanid, and growing evidence for the use of linezolid, offer renewed hope for addressing MDR-TB. However, access to these medicines remains a significant challenge. These drugs have not been registered for TB in most settings; barriers to preapproval access persist; and high pricing and intellectual property restrictions limit access. Many unanswered research questions about optimal use of these drugs also limit access, particularly for vulnerable populations. This review outlines challenges in accessing drugs encountered from the perspective of clinicians, patients and affected communities, and offers potential solutions.
Databáze: Directory of Open Access Journals