| Autor: |
Gabriella Leone, Danilo Vona, Elvira De Giglio, Maria Addolorata Bonifacio, Stefania Cometa, Saverio Fiore, Fabio Palumbo, Roberta Ragni, Gianluca M. Farinola, Stefania R. Cicco |
| Jazyk: |
angličtina |
| Rok vydání: |
2019 |
| Předmět: |
|
| Zdroj: |
Data in Brief, Vol 24, Iss , Pp - (2019) |
| Druh dokumentu: |
article |
| ISSN: |
2352-3409 |
| DOI: |
10.1016/j.dib.2019.103831 |
| Popis: |
Diatoms are unicellular photosynthetic microalgae that produce a sophisticated mesoporous biosilica shell called frustule. Easy to achieve and extract, diatom frustules represent a low-cost source of mesoporous biocompatible biosilica. In this paper, the possibility to in vivo functionalize the diatom biosilica with bisphosphonates (BPs) was investigated. In particular, two BPs were tested: the amino-containing sodium alendronate (ALE) and the amino-lacking sodium etidronate (ETI). According to first SEM-EDX analysis, the presence of the amino-moiety in ALE structure allowed a better incorporation of this BP into living diatom biosilica, compared to ETI. Then, diatom growth was deeply investigated in presence of ALE. After extraction of functionalized frustules, ALE-biosilica was further characterized by XPS and microscopy, and ALE release was evaluated by ferrochelation assay. Moreover, the bone regeneration performances of ALE-functionalized frustules were preliminarily investigated on bone osteoblast-like cells, via Comassie staining. Data are related to the research article “In vivo functionalization of diatom biosilica with sodium alendronate as osteoactive material”. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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