| Autor: |
E. Villegas-Becerril, C. Jimenez-Garcia, L.A. Perula-de Torres, M. Espinosa-Calvo, C.M. Bueno-Serrano, F. Romero-Ruperto, F. Gines-Santiago, M.C. Moreno-Manzanaro, J.J. Muñoz-Gavilan, G. Montes-Redondo, M.A. Quesada-Roman, M.C. Linares-Ramirez, J.M. Parras-Rejano, N. Muñoz-Alcaraz, M.D. Maestre-Serrano, E.M. Romero-Rodriguez |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
Contemporary Clinical Trials Communications, Vol 39, Iss , Pp 101288- (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2451-8654 |
| DOI: |
10.1016/j.conctc.2024.101288 |
| Popis: |
Objectives: Radiation-induced dermatitis (RD) is one of the most common toxicities in radiation therapy (RT) patients. Corticosteroids, immunosuppressants, and natural products (NPs) have been used as treatment. The objective was to evaluate the efficacy of a NPs-based cream (Alantel®) to reduce the incidence of RD in women with breast cancer undergoing RT treatment. Design: We conducted a controlled, randomized, double-blind clinical trial. Setting: Radiation Oncology Unit of the Reina Sofía Hospital and 5 Primary Care centers of the Cordoba and Guadalquivir Health District (Spain). Interventions: Patients assigned to the experimental group (GTA) were treated with Alantel, while those in the control group (GTE) were treated with a moisturizer and emollient cream. Main outcome measures: The primary outcome variable was the incidence of RD. RD-free time, duration of RD, quality of life, and product safety were also assessed. Results: Seventy patients were included in the study, 35 in the GTA and 35 in the GTE. The incidence of RD was lower in the GTA (71.4%) than in the GTE (91.4%) after 4 weeks of follow-up (RR = 0.78; NNT = 5; p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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