| Autor: |
Dmitri Simberg, S. Moein Moghimi |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
Journal of Nanotheranostics, Vol 5, Iss 3, Pp 99-103 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2624-845X |
| DOI: |
10.3390/jnt5030007 |
| Popis: |
PEGylation technology confers stability and modulates the biological performance of a broad range of preclinical and clinical nanopharmaceuticals. However, the emerging PEG immunogenicity in the general population is thought to impact the efficacy and safety of PEGylated medicines. Despite this, the clinical significance of PEG immunogenicity is still not clear and remains debatable. By considering the strategic importance of the PEGylation technology in nanopharmaceutical engineering, we raise a number of critical questions and briefly discuss gaps in the knowledge of PEG immunogenicity and its clinical significance. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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