Design, synthesis, characterization and antimicrobial screening of newly synthesized indazoles of vanillin analogues
| Autor: | Krushnakumar L. Karangiya, Manoj F. Dhaduk, Jatin J. Upadhyay |
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| Jazyk: | angličtina |
| Rok vydání: | 2025 |
| Předmět: | |
| Zdroj: | Current Chemistry Letters, Vol 14, Iss 1, Pp 51-58 (2025) |
| Druh dokumentu: | article |
| ISSN: | 1927-7296 1927-730X |
| DOI: | 10.5267/j.ccl.2024.10.002 |
| Popis: | A series of 6-(Aryl)-4-[4-(2,4-dichlorophenylmethoxy)-3-methoxyphenyl]-2,3,4,5-tetrahydro-indazol-3-one derivatives (3a-3i) have been synthesized by refluxing of previously synthesized Ethyl-4-(aryl)-6-[4-(2,4-Dichlorophenylmethoxy)-3-methoxyphenyl]-2-oxo-cyclohex-3-eneoates (2a-2i) with hydrazine hydrate in methanol for 7-8 hours in presence of catalytic amount of glacial acetic acid. The analytical and physical data of all the synthesized compounds (2a-2i) and (3a-3i) were observed and reported. The structures of each newly synthesized Indazole derivative have been characterized by various methods like Elemental analysis, Infrared spectroscopy, 1H-NMR and 13CMR spectroscopy and Mass spectroscopy. Furthermore, each compound was screened for its in-vitro antibacterial activity towards Gram-positive and Gram-negative bacterial strains and antifungal towards fungi Aspergillus niger (A. niger) and Candida albicans (C. albicans) with the concentration of 40 μg/ml and data was collected. |
| Databáze: | Directory of Open Access Journals |
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