| Autor: |
Seher Yi̇lmaz, Yeşim Göçmen, Adem Tokpınar, İlyas Uçar, Şükrü Ateş, Seda Avni̇oğlu, Mehtap Ni̇sari̇ |
| Jazyk: |
English<br />Turkish |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
Acta Medica Alanya, Vol 4, Iss 2, Pp 150-155 (2020) |
| Druh dokumentu: |
article |
| ISSN: |
2587-0319 |
| DOI: |
10.30565/medalanya.688286 |
| Popis: |
Aim: Paracetamol is widely used by important societal groups such as pregnant women and the elderly. Paracetamol, taken in high doses especially during pregnancy, causes liver failure. The aim of our study is to investigate the effects of paracetamol, which is widely used during pregnancy, on the fetal liver. Methods: In our study, five groups of randomly selected rats from 10 Wistar Albino rats (n=2) were formed as control group, 50 mg / kg paracetamol group, 125 mg / kg paracetamol group, 250 mg / kg paracetamol group and 500 mg / kg paracetamol group. Paracetamol by gavage was given to pregnant rats in specified doses. Fetuses were taken by cesarean on the 20th day of pregnancy (10 fetuses were taken from each group). The fetus livers were then taken for biochemical analysis. Biochemically, vascular endothelial growth factor A (VEGF-A), FETU-A (FETUIN-A) (α2-heremans-schmid glikoprotein) and Sclerostin (SOST) values were examined.Results: In this study, changes in liver hepatocyte cells are seen as the dose of paracetamol increases. Regular increase is observed in VEGF-A and FETU-A. SOST increased at a dose of 250 mg / kg and decreased in the group of 500 mg / kg paracetamol. (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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