| Autor: |
Pratik Patel, Bhavin Patel, Megha Patel, Paresh Patel |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
Results in Chemistry, Vol 7, Iss , Pp 101377- (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2211-7156 |
| DOI: |
10.1016/j.rechem.2024.101377 |
| Popis: |
A novel series of 4-morpholino-5,8,9,10-tetrahydropyrimido[4,5–b]quinolin-6(7H)-one has been synthesized by an extremely effective, straightforward and clean methodology for one-pot multicomponent condensation reaction (MCRs) utilizing polyphosphoric acid as a catalyst in conjunction with acetic acid. The three-components 4-amino-6-morpholinopyrimidine, cyclohexane-1,3-dione and various aromatic aldehydes resulted in the synthesis of high-yielding compounds, to gauge their in vitro antimalarial activity toward P. falciparum 3D7 strain cultures. The compounds demonstrated outstanding inhibition with IC50 values ranging from 0.62 to 0.84 μg/mL. Compounds 3c and 3e exhibited the most significant action with IC50 values of 0.62 μg/mL which is also supported by in silico ADME and molecular docking study. These newly synthesized pyrimido[4,5–b]quinolines aim to enhance antimalarial drugs, potentially opening up new routes in pharmaceutical chemistry. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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