Clinical value of serum complement component 1q levels in the prognostic analysis of aneurysmal subarachnoid hemorrhage: a prospective cohort study
| Autor: | Linjie Wang, Haotian Zhou, Wenhao Zheng, Heng Wang, Zheng Wang, Xiaoqiao Dong, Quan Du |
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| Jazyk: | angličtina |
| Rok vydání: | 2024 |
| Předmět: | |
| Zdroj: | Frontiers in Neurology, Vol 15 (2024) |
| Druh dokumentu: | article |
| ISSN: | 1664-2295 05081432 |
| DOI: | 10.3389/fneur.2024.1341731 |
| Popis: | ObjectiveTo analyze the relationship between serum complement component 1q (C1q) levels and functional prognosis in patients with aneurysmal subarachnoid hemorrhage (aSAH), and to reveal its clinical value.MethodsIn this prospective cohort study, we collected clinical data of aSAH patients admitted to the Department of Neurosurgery, Hangzhou First People’s Hospital from January 2020 to October 2022. Parameters such as serum C1q levels, Hunt-Hess grade, modified Fisher grade, and the modified Rankin scale (mRS) at 3 months were included for evaluation. Patients were grouped based on the occurrence of delayed cerebral ischemia (DCI). Spearman rank correlation test and Kruskal-Wallis rank sum test were used to analyze the correlation between serum C1q levels, disease severity, and prognosis. Potential risk factors affecting prognosis and the occurrence of DCI were screened through Independent sample t-test or Mann–Whitney U test. Variables with significant differences (p |
| Databáze: | Directory of Open Access Journals |
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