T-Plastin reinforces membrane protrusions to bridge matrix gaps during cell migration

Autor: Damien Garbett, Anjali Bisaria, Changsong Yang, Dannielle G. McCarthy, Arnold Hayer, W. E. Moerner, Tatyana M. Svitkina, Tobias Meyer
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-020-18586-3
Popis: In vivo, cells migrate across a diverse landscape of extracellular matrix containing gaps which present a challenge for cells to protrude across. Here, the authors show that T-Plastin strengthens protrusive actin networks to promote protrusion, extracellular matrix gap-bridging, and cell migration.
Databáze: Directory of Open Access Journals