| Autor: |
Oscar Bladh, Katherina Aguilera, Ulrika Marking, Martha Kihlgren, Nina Greilert Norin, Anna Smed-Sörensen, Margaret Sällberg Chen, Jonas Klingström, Kim Blom, Michael W. Russell, Sebastian Havervall, Charlotte Thålin, Mikael Åberg |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
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| Zdroj: |
Frontiers in Immunology, Vol 15 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
1664-3224 |
| DOI: |
10.3389/fimmu.2024.1346749 |
| Popis: |
IntroductionSeveral novel vaccine platforms aim at mucosal immunity in the respiratory tract to block SARS-CoV-2 transmission. Standardized methods for mucosal sample collection and quantification of mucosal antibodies are therefore urgently needed for harmonized comparisons and interpretations across mucosal vaccine trials and real-world data.MethodsUsing commercial electrochemiluminescence antibody panels, we compared SARS-CoV-2 spike-specific IgA and IgG in paired saliva, nasal secretions, and serum from 1048 healthcare workers with and without prior infection.ResultsSpike-specific IgA correlated well in nasal secretions and saliva (r>0.65, p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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