Childhood core binding factor (CBF) acute myeloid leukemia and its association with French American British (FAB) classification

Autor: Naeem Jabbar, Neelum Mansoor, Sidra Maqsood, Zaid Muhammad Aslam, Anzal Taufeeq Jangda, Syed Ahmer Hamid
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Journal of the Pakistan Medical Association (2020)
Druh dokumentu: article
ISSN: 0030-9982
DOI: 10.47391/JPMA.521
Popis: Abstract Objective: To find the frequency of core binding factor acute myeloid leukaemia in our population, and to determine its association with morphological subtypes. Methods: The retrospective study was conducted at The Indus Hospital, Karachi, and comprised data of patients aged 1-17 years who were diagnosed with acute myeloid leukaemia from July 2013 to June 2017. Data was analysed using SPSS 21. Results: Of the 237 patients, 137(58%) were males and 100(42%) were females. The overall mean age was 8±4.34 years. Cytogenetic testing had been performed in 212(89.45%) cases, and core binding factor was detected in 72(34%) cases. There was significant difference between the mean values of white cell count and the subtypes (p=0.000). Also the difference between core binding factor and the subtypes was significant (p=0.000). Conclusion: There was found to be a significant association of core binging factor with specific subgroups of acute myeloid leukaemia. Key Words: Acute myeloid leukaemia, Core binding factor, Cytogenetic abnormalities, Prognosis. Continuous....
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