Dupilumab in a patient with severe asthma and glucocorticoid hypersensitivity: a case report
Autor: | Hiroshi Handa, Hajime Tsuruoka, Kohei Kinoshita, Masamichi Mineshita |
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Jazyk: | angličtina |
Rok vydání: | 2023 |
Předmět: | |
Zdroj: | Journal of International Medical Research, Vol 51 (2023) |
Druh dokumentu: | article |
ISSN: | 1473-2300 03000605 |
DOI: | 10.1177/03000605231193922 |
Popis: | Recently, several biologics have been approved for the treatment of severe asthma. Dupilumab, a biologic used to treat severe asthma, is a monoclonal antibody targeting interleukin-4 and interleukin-13. In the present case, inhaled corticosteroid-induced glucocorticoid hypersensitivity was suspected, and the administration of omalizumab and mepolizumab had no beneficial effects. Subsequently, we switched to dupilumab therapy, which produced better effectiveness. Therefore, when a biologic agent proves ineffective, changing to another suitable biologic agent should be considered. |
Databáze: | Directory of Open Access Journals |
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