| Autor: |
Miłosz Parczewski, Magdalena Leszczyszyn-Pynka, Magdalena Witak-Jędra, Bartosz Szetela, Jacek Gąsiorowski, Brygida Knysz, Monika Bociąga-Jasik, Paweł Skwara, Anna Grzeszczuk, Maria Jankowska, Grażyna Barałkiewicz, Iwona Mozer-Lisewska, Władysław Łojewski, Katarzyna Kozieł, Edyta Grąbczewska, Elżbieta Jabłonowska, Anna Urbańska |
| Jazyk: |
angličtina |
| Rok vydání: |
2017 |
| Předmět: |
|
| Zdroj: |
PLoS ONE, Vol 12, Iss 2, p e0172473 (2017) |
| Druh dokumentu: |
article |
| ISSN: |
1932-6203 |
| DOI: |
10.1371/journal.pone.0172473 |
| Popis: |
INTRODUCTION:Reconstruction of HIV transmission links allows to trace the spread and dynamics of infection and guide epidemiological interventions. The aim of this study was to characterize transmission networks among subtype B infected patients from Poland. MATERIAL AND METHODS:Maximum likelihood phylogenenetic trees were inferred from 966 HIV-1 subtype B protease/reverse transcriptase sequences from patients followed up in nine Polish HIV centers. Monophyletic clusters were identified using 3% within-cluster distance and 0.9 bootstrap values. Interregional links for the clusters were investigated and time from infection to onward transmission estimated using Bayesian dated MCMC phylogeny. RESULTS:Three hundred twenty one (33.2%) sequences formed 109 clusters, including ten clusters of ≥5 sequences (n = 81, 8.4%). Transmission networks were more common among MSM (234 sequences, 68.6%) compared to other infection routes (injection drug use: 28 (8.2%) and heterosexual transmissions: 59 (17.3%) cases, respectively [OR:3.5 (95%CI:2.6-4.6),p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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